Natural Products from Actinomycetes: Diversity, Ecology and Drug Discovery, (Hardcover)

<p><b>Section 1: Diversity, Chemical biology and Ecology of Actinomycetes; and the Discovery of Natural Products</b></p> <p><b> </b></p> <p>Chapter 1: An overview on Natural products from Actinomycetes: their discovery and biosynthesis. </p> Chapter 2: Isolation, identification (cultural and molecular techniques), and systematics of Actinomycetes from various sources (marine, soil, extremophilic environment).<p></p> <p>Chapter 3: Studies on diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Actinomycetes strains.</p> <p>Chapter 4: Chemical elicitors and signaling molecules and their role in elicitation of secondary metabolism in Actinomycetes.</p> <p>Chapter 5: Regulation of antibiotic biosynthesis genes in Actinomycetes at molecular level.</p> <p>Chapter 6: Screening strategies for inhibitors against cancer cells from natural Products repository of Actinomycetes.</p> <p>Chapter 7: Rare and endophytic Actinomycetes in the biosynthesis of bioactive metabolites.</p> Chapter 8: Advances in bioactivity guided isolation of natural products from Actinomycetes.<p></p> <p>Chapter 9: Natural product discovery from non-Streptomyces Actinomycetes.</p> <p>Chapter 10: Use of high-efficiency CRISPR/Cas9-mediated genome editing to study biology of Actinomycetes.</p> <p><b> </b></p> <p><b>Section 2: Genomic approaches and synthetic biology tools in Actinomycetes drug discovery and industrial compounds</b></p> <p> </p> <p>Chapter 11: An overview of biomedical, biotechnological and industrial applications of Actinomycetes</p> Chapter 12: Genomics and proteomics approach in natural product discovery in Actinomycetes.<p></p> <p>Chapter 13: Structural dereplication and strain dereplication strategies and metabolomics in natural product research.</p> <p>Chapter 14: Genome mining of rare Actinomycetes and cryptic pathways for secondary metabolites.</p> <p>Chapter 15: Glycosylated bioactive compound discovery by from Actinomycetes by combination of genome mining, gene inactivation and activation of silent biosynthetic clusters.</p> <p>Chapter 16: Genetic engineering for overproducing bioactive secondary metabolites in Actinomycetes</p> <p>Chapter 17: Transcriptional gene cluster refactoring for increased secondary metabolites production </p> <p>Chapter 18: Synthetic biology in Actinomycetes for natural product discovery</p> <p>Chapter 19: Metabolic engineering of antibiotic factories: new tools for antibiotic production in Actinomycetes</p> <p>Chapter 20: Bioinformatic tools for use in pks and nrps discovery in Actinomycetes.</p> <p> </p>

• Natural Products from Actinomycetes: Diversity, Ecology and Drug Discovery, (Hardcover)
• Author: Springer
• ISBN: 9789811661310
• Format: Hardcover
• Publication Date: 2022-04-16
• Page Count: 508